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Researchers report breakthrough in ALS cause
Source:
(AHN)
Reporter:
Diane Alter
Location:
Chicago, IL, United States
Published:
August 23, 2011 11:56 am EDT
Topics:
Health, Medical Conditions, Science And Technology, Research
A study at Northwestern University's Feinberg School of Medicine has identified a common cause of all forms of ALS.
ALS, or amyotrophic lateral sclerosis, is a fatal neurodegenerative disease that paralyzes its victims. Also known as Lou Gehrig's disease, the disorder has long puzzled scientists and there are currently no effective treatments.
The Northwestern researchers found the basis of ALS to be a malfunctioning protein recycling system in the neurons in the brain and the spinal cord. Efficient recycling of the protein building blocks in the neurons are imperative for optimal functioning of the neuron. When they cannot repair or maintain themselves, they become severely damaged. This problem occurs in all types of ALS: hereditary, sporadic and ALS that attacks the brains, researchers noted.
The findings open up an entirely fresh field for treating the disease. About 350,000 people worldwide suffer from ALS, and about 50 percent of patients die within three years of the first symptoms. ALS sufferers lose muscle strength, eventually becoming paralyzed and unable to move, swallow, speak or breathe.
The discovery was published Sunday in the journal Nature.
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