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Advertisement Researchers unlock one of the Ebola virus' mysteries Findings could be used to prevent virus outbreaks and stave off bioterrorism possibilities. Source: (AHN) Reporter: Ayinde O. Chase Location: New York, NY, United States Published: August 24, 2011 08:09 pm EDT Topics: Science And Technology, Research, Health, Illness, Science And Technology, Biotechnology Researchers at Albert Einstein College of Medicine of Yeshiva University have helped uncover a cellular protein that is critical for infection by the deadly Ebola virus. The findings, suggest a possible strategy for blocking infection due to Ebola virus, one of the world's most lethal viruses and virus which can be used as bioterrorism weapon. Researchers from Einstein, the Whitehead Institute for Biomedical Research, Harvard Medical School, and the U.S. Army Medical Research Institute of Infectious Diseases all participated in the novel. Ebola virus is notorious for killing up to 90 percent of the people it infects. Ebola hemorrhagic fever – the severe, usually fatal disease that Ebola virus causes in humans and in nonhuman primates – first emerged in 1976 in villages along the Ebola River in the Sudan and the Democratic Republic of the Congo, Africa. Since then, about two dozen outbreaks have occurred. The Ebola virus binds to the host cell's outer membrane, and a portion of host cell membrane then surrounds the virus and pinches off, creating an endosome – a membrane-bound bubble inside the cell. Endosomes carry their viral stowaways deep within the cell and eventually mature into lysosomes – tiny enzyme-filled structures that digest and recycle cellular debris. The viruses captive in the lysosome manage to escape destruction by exploiting components of the cell to gain entry to the cytoplasm, the substance between the cell membrane and the nucleus where the virus can replicate. However before now the identities of many of these components have remained unknown. "We found that if your cells don't make this protein, they cannot be infected by Ebola virus," said Dr. Chandran. "Obviously it's very early days, but we think our discovery has created a real therapeutic opportunity." Currently there are no drugs available to treat people who have been infected with Ebola virus or approved vaccines to prevent illness. The discovery of NPC1's crucial role in Ebola infection raises the possibility that Ebola and Marburg virus outbreaks could be thwarted by a drug that blocks the action of NPC1. Republish Email Facebook Digg Twitter Share Copyright © 2011 AHN - All rights reserved.Content including text, photos, videos, audio, graphics and logos may not be used for commercial purposes, reproduced, published, broadcast, rewritten for broadcast or publication or redistributed directly or indirectly in any medium without permission and license from AHN. 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