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The soldiers, five from the 3rd Battalion the Yorkshire Regiment and one from the 1st Battalion The Duke of Lancaster's Regiment, were on a mounted patrol on Tuesday when their Warrior Armored Fighting Vehicle was struck, the British Ministry of Defense said. "One of the Warriors suffered catastrophic damage in the course of that explosion," Brigadier Patrick Sanders, commander of Task Force Helmand, told journalists in the provincial capital Lashkar Gah. The attack, on Helmand's border with the unruly Kandahar province, marked the biggest single loss of life for British troops in Afghanistan since 2006. Britain is the second largest contributor to the NATO-led war after the United States. The Britons' vehicle was hit by a roadside bomb, the deadliest weapon used by insurgents, said senior Afghan police official Mohammad Ismail Hotak in Helmand. "It is a reminder of the huge price that we are paying for the work we are doing in Afghanistan and the sacrifice that our troops have made and continue to make," British Prime Minister David Cameron told the BBC. "I do believe it's important work for our national security right here at home but of course this work will increasingly be carried out by Afghan soldiers and we all want to see that transition take place." Foreign combat troops are due to leave Afghanistan at the end of 2014. Doubts persist about the ability of Afghan soldiers and police to control one of the world's most unstable countries. Britain has around 9,500 soldiers in Afghanistan, a number due to be reduced in phases as it ends combat operations in the next two years. Task Force commander Sanders said Tuesday's attack had "a significant impact emotionally. These are comrades." But describing the assault as a "one-off," he stressed that such a large loss of life runs contrary to the trend of the last eight or twelve months in Helmand. Referring to the fact the number of British deaths in the Afghan war had exceeded 400, a senior British military source in Helmand said: "I don't think soldiers see these round numbers, psychological milestones." "It's disappointing to have this at the end of the tour but at this stage in the tour with how much progress we've made, we're able to contextualize this," he added. (Additional reporting by Michael Holden in LONDON; Editing by Michael Georgy, Nick Macfie and Ed Lane) World Afghanistan Tweet this Link this Share this Digg this Email Reprints We welcome comments that advance the story through relevant opinion, anecdotes, links and data. If you see a comment that you believe is irrelevant or inappropriate, you can flag it to our editors by using the report abuse links. 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