InfoAnda - Scientists turbo-charge immune cells to fight cancer

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Navigation Primary Navigation Home Singapore Asia Pacific World Business Entertainment Sports Technology Secondary Navigation Top Stories Full Coverage Most Popular Photos Search Search: Scientists turbo-charge immune cells to fight cancer AFP - Monday, November 3 PARIS (AFP) - - Scientists in the United States have created super-charged immune cells that helped beat back cancer tumours in half of a small group of patients tested, according to a study released Sunday. Adding an artificial receptor to T-lymphocytes immune cells boosted their ability to fight a deadly form of cancer called neuroblastoma, the researchers reported. Neuroblastoma attacks the nervous system. While fairly rare, it accounts for seven percent of all childhood cancers, and 15 percent of non-adult cancer deaths. In two-thirds of cases, it is not diagnosed until it has already spread to other parts of the body. In their natural state, T-lymphocytes do not survive very long and lack the molecules that would target cancer cells in tumours. To overcome this double deficiency, a team of researchers led by Malcolm Brenner at the Baylor College of Medicine in Houston, Texas first selected immune cells naturally stimulated by a common but harmless virus called Epstein-Barr. They then modified these cells to express a receptor keyed to specific proteins found in human neuroblastoma cells. "In effect, the T-lymphocytes trampoline off the virus and onto the tumor," said Brenner. In tests on 11 neuroblastoma patients aged three to 10, the re-engineered immune cells -- stimulated by the Epstein-Barr virus -- lasted for as long as 18 months, the study reported. In five cases, tumours regressed and in a sixth the disease receded completely. "For the first time, we started to see tumour responses," Brenner said. "We have one complete remission and others who have had stable disease for more than a year." In future research, Brenner and his team plan to add receptors for other cancers to see if they get the same cancer-fighting effect, he said. The study was published online in the Nature Publishing Group's journal Nature Medicine. Email Story IM Story Printable View Blog This Recommend this article Average (0 votes) Sign in to recommend this article » Most Recommended Stories » Enlarge Photo Scientists in the United States have created super-charged immune cells that helped beat back cancer tumours in half of a small group of patients tested, according to a study released Sunday. Most Popular – Top Stories Viewed Obama and McCain hurtle into final 48 hours Australian F1 race posts record financial loss Hamilton pips Massa to Formula One title in tense Brazil finale Australia anxious as Indonesia prepares to execute Bali bombers Hamilton says he is not feeling the strain View Complete List » Search: Home Singapore Asia Pacific World Business Entertainment Sports Technology

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