InfoAnda - Faulty gene condemns millions in India to heart disease: study

Pakistanis angry over detentions in Times Sq. case
Monday, May 24, 2010
ISLAMABAD – Relatives of three men detained by Pakistan for alleged links to the suspect in the attempted Times Square bombing say the men are innocent.
They

Taiwan denies boycotting Australian film festival
Thursday, August 6, 2009

AFP - Thursday, August 6TAIPEI (AFP) - - Taiwan's Beijing-friendly government on Wednesday denied boycotting an Australian film festival amid a row over the e

Merkel's support dips, regional ally resigns International
Thursday, September 3, 2009

By Sarah Marsh and Noah Barkin

BERLIN (Reuters) - Chancellor Angela Merkel suffered a double blow on Thursday as a senior party ally in east German

Minister seeks closure of anti-Berlusconi websites
Wednesday, December 16, 2009
ROME (AFP) - – The Italian government moved Tuesday to close down Internet sites encouraging further violence against Prime Minister Silvio Berlusconi, who

Asian markets mixed after Wall Street rally
Wednesday, March 18, 2009

By ELAINE KURTENBACH,AP Business Writer AP - Wednesday, March 18SHANGHAI - Asia's stock market rally seemed to be running out of steam Wednesday, despite an

911 caller: Pitchman Mays found cold, unresponsive | 30 June 2009
Retail giant Baugur seeks bankruptcy protection | 5 February 2009
Hollywood eyes Michael Jackson movie: report | 22 July 2009

Medvedev visit showcases warmer US-Russia ties | 23 June 2010

">Forum Views () ">Forum Replies ()

Read more with google mobile : Faulty gene condemns millions in India to heart disease: study

Navigation Primary Navigation Home Singapore Asia Pacific World Business Entertainment Sports Technology Top Stories Most Popular Secondary Navigation Search Search: Faulty gene condemns millions in India to heart disease: study AFP - Monday, January 19 PARIS (AFP) - - Tens of millions of people from the Indian subcontinent are destined to suffer heart disease due to a single genetic mutation, according to a study released Sunday. The wayward gene, found almost exclusively among the more than 1.5 billion people in or from South Asia, is almost guaranteed to lead to heart trouble, usually later in life, the researchers reported. Four percent of the region's population -- some 60 million people -- carry the mutation, concludes the study, published in Nature Genetics. Scientists have long suspected that India, Pakistan, Sri Lanka and probably Bangladesh carry an outsized share of the global burden of heart disease. One recent study predicts that by the end of this year India alone will account for 60 percent of the world's heart-related problems, which can have both lifestyle and genetic origins. The new research by an international team of 25 scientists and doctors from four countries provides a partial answer as to why this is so: an unexpectedly common defect in a gene, MYBPC3, that provides the blueprint for a certain kind of heart protein. "The mutation leads to the formation of an abnormal protein," said the study's main architect, Kumarasamy Thangaraj of the Centre for Cellular and Molecular Biology in Hyderbad, India. "Young people can degrade the abnormal protein and remain healthy, but as they get older it builds up and eventually results in the symptoms that we see." These include severe hypertension, an inflammation and weakening of the heart called cardiomyopathy, and death due to sudden cardiac arrest. Thangaraj and colleagues first discovered the mutation -- the deletion of 25 bits of genetic code -- five years ago in two Indian families. But its significance only came to light with the new research. In two separate clinical tests, researchers checked for the presence of the variant in 800 heart patients and 699 healthy individuals across India. The link between the symptoms and the genetic defect "were almost off the scale," leaving no doubt that the mutation played a key role in causing heart disease. Further tests in different parts of the country of 28 unrelated families carrying the mutation showed that more than 90 percent of the oldest members in each family had heart problems. While virtually absent among peoples from other parts of the world, the deadly genetic variant is equally spread across most of India's regions, its social castes, as well as its language and religious groups. In a follow-up sampling of more than 2,000 indigenous individuals from 26 countries across five continents, the telltale mutation showed up in Pakistan and Sri Lanka, with some presence in Malaysia and Indonesia, but nowhere else. The findings raise a perplexing question: if the bit of missing genetic code is so harmful, how did it become so common? Why did it not die out over the course of evolution, as usually happens to maladapted genes? "The harmful effects are felt mainly late in life after people have had their children, so the mutation is essentially invisible to natural selection," explained co-author Chris Tyler-Smith, a researcher at The Wellcome Trust Sanger Institute in Hinxton, England. "When carriers have children, the genes remain in the population," he told AFP by phone. While many diseases hit in old age, very few are caused by a single mutation. "The only other example I can think of is Alzheimer's, where there is a variant that affects the very late-onset form of the disease," Tyler-Smith said. The MYBPC3 variant, he added, probably accounts for no more than five percent of heart disease in India, but still affects tens of millions of people. "The bad news is that many of these mutation carriers have no warning that they are in danger," said Perundurai Dhandapany of Madurai Kamaraj University in Madurai, India. "But the good news is that we now know the impact of the mutation." The researchers said the findings should lead to better screening to identify those at risk, and may ultimately pave the way for the development of new treatments. An estimated 17 million people around the world die of cardiovascular diseases every year, particularly heart attacks and strokes. Email Story IM Story Printable View Blog This Recommend this article Average (0 votes) Sign in to recommend this article » Most Recommended Stories » Enlarge Photo Doctors perform heart surgery. Tens of millions of people from the Indian subcontinent are destined to suffer heart disease due to a single genetic mutation, according to a study released Sunday. Most Popular – Top Stories Viewed Zimbabwe unveils $100 trillion banknote 'Dogs don't wear condoms,' says Baywatch star Anderson Hamas announces one-week truce after Israel ceasefire All aboard, as Obama takes slow train to power Hormone drives sexy women to infidelity, says study View Complete List » Search: Home Singapore Asia Pacific World Business Entertainment Sports Technology Top Stories Most Popular

Other News on Monday, 19 January 2009
Israel forces start Gaza withdrawal
Suicide bomber kills campaign manager in Iraq
Merkel's CDU trounces SPD in state election: exit poll
Gaza truce takes hold; Israeli pullout begins
North Korea says plutonium weaponized and off-limits | International |
French army helicopter crashes, eight dead or missing
Israelis begin gradual Gaza pullout: army
Obama raring to go as historic inauguration looms
Afghanistan held back by weak leadership: NATO | International |
Al Qaeda threatens German soldiers in web video | International |
China reports two new cases of bird flu, one dead | International |
Suicide bomber kills deputy head of Iraq Sunni party | International |
Thousands at risk as Darfur fighters prepare attack: U.N. | International |
China reports second bird flu death this month
Philippine celebrity maid fights abuses with songs
Palm oil frenzy threatens to wipe out orangutans
Needy residents get help ahead of Budget measures
Celebration and solemnity as Obama nears inauguration
Indian Muslim groups have role to play in tough economic times
Obama's speech will call for new era of responsibility: aides
Singapore government may dip into reserves
Democrats Say They Want Criminal Probes Into Bush Administration
Explosion at fuel depot in Indonesian capital
Convicted Murderer Escapes From Maryland Prison
Yachting: Volvo Ocean Race boats leave Singapore for China
Hedge Fund Manager Disappears With Millions In Clients' Money
Fann Wong, Christopher Lee witness 20 couples renew their wedding vows
South West CDC promotes cost—saving eco—projects among households
Mariah Carey goes from Glitter to grim at Sundance | Entertainment |
Kevin James is top Cop with box office hit | Entertainment |
Gisele comes home to strut Sao Paulo Fashion Week
Kevin James is top "Cop" with box office hit
Sundance doc wants people to know 'it's Cazale'
Mariah Carey goes from "Glitter" to grim at Sundance
Hamas and Israel hold fire as Gazans reel at war's toll
Hamas and Israel hold fire as Gazans reel at war's toll | International |
Egypt summit ups pressure on Israel to quit Gaza
Britain to unveil second bank bailout package
Denmark agrees on 13.4-bln-euro line of credit to banks: govt
'Overwhelming emotion' at star-studded inaugural concert
Faulty gene condemns millions in India to heart disease: study
China's civil service exam cheaters go high-tech | International |
US military deaths in Iraq war at 4,228
Singapore considers tapping reserves amid recession-report
US Airways jet black box points to bird collision
Pakistan: Destroyed girls' schools to reopen soon
US Air flight recorders indicate bird collision: officials
NKorea set to test Obama's resolve: analysts
Obama urges national struggle as inauguration looms
Seoul shares open up led by techs; LG Display up
Taiwan's once-world beating memory chip makers face tough times
Sundance gives rise to star documentaries | Entertainment |
Inaugural party on TV: serious with bit of goofy
Obamas, Bidens enjoy Lincoln Memorial concert
Sundance gives rise to star documentaries
Shackleton team descendants reach the South Pole
'Overwhelming emotion' at star-studded Obama inaugural concert
French honour for folk singer Donovan, countertenor Jaroussky
Big bucks keep North American box office busy
With economy, no campaign, TV news eyes challenges
Afghans not expecting much change under Obama
South Korea's Lee names hardliner to North post | International |
Change.gov coming to the White House
Merkel kicks off re-election year facing wounded SPD
Church roof collapse kills at least seven Brazil | International |
Obama to honor Martin Luther King ahead of inauguration
Regional leaders resume push to end Zimbabwe crisis | International |
Cardinals, Steelers book Super Bowl showdown
O'Sullivan captures fourth British Masters snooker title
Riots expose roots of anger on EU's edges | International |
Further custody extension for Mumbai attacker: police
Obama urges national struggle as inauguration looms
Russia devalues rouble for sixth time in 2009
Interpol alert over multi-million-dollar Singapore theft
Oil in narrow trading range in Asia
Sri Lankan military battles rebels in north
Cheaters use spy gear on China's civil service exam: state media
Sri Lanka's most wanted Tiger running out of options
3 Indonesian robbers killed in Malaysia shootout
Thai PM holds talks on migrant abuse allegations
Sluggish economy won't cramp fitness in Asia-survey
China to mark defeat of Tibetan rebellion
Seoul shares up helped by techs, cabinet reshuffle
FACTBOX-Penpix of S.Korea's new fin min, top fin regulator
WRAPUP 2-S.Korea revamps cabinet to fight crisis
China to inject 1.5 billion dollars into power sector: report
Japan's industrial output drops 8.5 percent in November
Philippine budget deficit to rise on more spending
South Korea replaces top econ, North policy makers
Chinese tycoon resigns from appliance giant Gome
Japan needs 'tenderhearted' capitalism, minister says
Air China expects to post 'significant loss' for 2008
Who makes the Obamas dance? Stevie Wonder! | Entertainment |
Audiences, critics give thumbs down to India-China film
Audiences, critics give thumbs down to India-China film
Around the world, atheists hit road to knock down God
Kenya looks to cash in on Obama pilgrims
Who makes the Obamas dance? Stevie Wonder!
To regain populist footing, Oscars need a hero
On historic steps, Obama's rise celebrated in song
Salman Rushdie reflects on 20-year-old fatwa
Dumpster couture makes foray into Obamaworld
Spain's canny chefs cook for credit crunch
Iran reportedly names two doctors in U.S.-backed plot
South Korea revamps cabinet to better fight crisis | International |
Eurozone economy to contract 1.9% in 2009: EU
Israel and Hamas truce holds on Gaza Strip
Russia and Ukraine aim to sign gas deal | International |
Europe sceptical over new Russia, Ukraine gas accord
Zimbabwe unity talks get underway
Broadway Show Producers File Grievance Complaint Against Jeremy Piven Over "Sushigate" Excuse
Iran names two doctors in U.S.-backed plot: report | International |
China warns of bird flu risk over Lunar New Year | International |
Pakistani Taliban blow up schools in Swat | International |
Suicide blast outside NATO Afghan base | International |
Australian gets three years for Thai royal insult | International |
Report: Iran dismantles a US-backed spy network
Pretrial hearings to begin for Guantanamo detainees
Cruise 'always wanted to kill Hitler'
Oil prices drop as weak demand bites
India keeps pressure on Pakistan over Mumbai
Suicide attack near US base kills 1 Afghan
Pakistani Taliban blow up schools in Swat
Widespread Recession Slows Down Domestic Migration In The U.S.
SKorea names new minister for NKorea
Inaugural Celebrations Kick Off With Bruce Springsten, Denzel Washington, Tiger Woods
Pakistan briefly halts US-NATO supplies
Bird Grounds Emergency Helicopter In Arkansas
MAS to tighten guidelines on sale of structured products
California Apartment Building Collapses, 4 Injured
Oil prices drop as weak demand bites
China reports second bird flu death this year
SKorea replaces finance minister to fight crisis
South Korea, EU launch high-level trade talks
Japan's Mazda to cut salaries, idle plants
Fitch cuts outlook for Taiwan's local currency
Citigroup says committed to Japanese units
China shares rise on buying by government fund
Japan's Nikkei slightly up on yen, Obama
Shanghai lawmakers slam 'Love China' cigarette ads
CHRONOLOGY-S.Korea acts to tackle financial, economic crisis
Sundance gives rise to star docs | Entertainment |
US-ENTERTAINMENT Summary
Winslet plans acceptance speech for BAFTAs
Saudi Cleric Upholds 'Fairness' Of Child Marriage
Beodica's Gold Unearthed
Witch Tapped To 'Haunt" Debt Dodgers
UN chief to visit Gaza on Tuesday: Israel
Iran students say time for U.S. to change policy | International |
Sudan opposition leader accused of Darfur rebel links
British trial seeks blindness cure: scientists
US-TECH Summary
India keeps pressure on Pakistan over Mumbai | International |
Abbas calls for Palestinian unity government, elections
South Korea's Lee names hardliner to North post | International |
"Lost In Space" Actor Bob May Dies
Sudan opposition leader accused of Darfur rebel links | International |
Photographer says Mugabe's wife beat him | International |
I'm a successful Somali pirate: Yassin's story | International |
U.S. anti-drug information leaked to Mexico cartels | International |
9/11 plotters appear before military judge
Bush phones world leaders
Militants in Pakistan bomb 5 schools, kill soldier
Karzai: Russia in defense deal with Afghanistan
Mobile carriers answer call for new services | Technology |
Police: 14 Indonesians die from home-brew alcohol
213 China families take milk case to highest court
Vatican to get own YouTube channel | Technology |
China reports 2nd bird flu death this year
T-Mobile to offer G1 in more European countries | Technology |
Civil servant rapped over cooking holiday
Pakistan militants bomb 5 schools in northwest
New ASEAN Basketball League to start in September
Various suggestions brought up at Singapore Perspectives Conference
Survey shows more high—income households turning to house brands
Ethics Of Using Own Kin For Scientific Data Gathering Raised
Empty Chicago Apartments Favorable For Renters
Circuit City Announces Plans To Continue Honoring Gift Certificates As It Closes 567 Outlets
Employee Productivity Expected To Receive A Boost If They Can Watch Inaugural While On The Job
Survey: Fewer Americans Consider Racism A Major Problem
Hong Kong stock market rises on US stimulus hopes
Taiwan's ProMOS sells equipment to Powertech
Asia, Europe officials warn against trade barriers
Gael Garcia Bernal does Cha Cha Cha at Sundance | Entertainment |
Dublin radio airs new U2 single
Scientists Use Own Children For Research
Tom Cruise 'always wanted to kill Hitler'
Storm, Not Disease Likely Caused Pelican Illnesses
Gael Garcia Bernal does Cha Cha Cha at Sundance
Obama A Good Ice Breaker To Ease Interracial Anxiety Between Blacks, Whites
Greece at new risk of being pushed off euro
Bodies of missing Tenn. mom, Jo Ann Bain, and daughter found
Female Breasts Are Bigger Than Ever
AMD Trinity Accelerated Processing Units Now in Volume Production
The Avengers (2012 film), made the second biggest opening- and single-day gross of all-time
AMD to Start Production of piledriver
Ivy Bridge Quad-Core, Four-Thread Desktop CPUs
Islamists Protest Lady Gaga's Concert in Indonesia
Japan Successfully Broadcasts an 8K Signal Over the Air
ECB boosts loans to 1 trillion Euro to stop credit crunch
Egypt : Mohammed Morsi won with 52 percent
What do you call 100,000 Frenchmen with their hands up
AMD Launches AMD Embedded R-Series APU Platform
Fed Should not Ignore Emerging Market Crisis
Fed casts shadow over India, emerging markets
Why are Chinese tourists so rude? A few insights

USD EUR - 1 year graph		BlogMeter 1.01